Title

Cyclodextrins in Ocular Drug Delivery

Document Type

Book Chapter

Publication Date

11-13-2016

Abstract

Cyclodextrins are a group of water-insoluble, donut-shaped, naturally occurring cyclic oligosaccharides that are produced as a result of the bacterial breakdown of α-d-glucose polymers, such as cellulose. They are inactive molecules that do not display any innate biological activity. The ocular delivery of certain drugs is affected not only by the drug’s physicochemical properties but also by the anatomical barriers of the eye. Drug-cyclodextrin complexes, formed by the physical occlusion of the torus cavity by the drug molecule, redress this issue. Thus, the ocular delivery of glaucoma drugs (e.g., carbonic anhydrase inhibitors, prostaglandin derivatives, pilocarpine), nonsteroidal anti-inflammatory drugs (e.g., indomethacin), and antifungal drugs (e.g., voriconazole) is enhanced by such inclusion complexes. Additionally, specific drug delivery systems (e.g., hydrogels, mucoadhesives, ocular gels) are harnessed to deliver the drug payload from the drug-cyclodextrin complex in a tunable fashion. This chapter seeks to elaborate on the chemical, biological, and pharmaceutical aspects governing cyclodextrins in the context of ocular drug delivery.

DOI

https://doi.org/10.1007/978-3-319-29346-2_12

Comments

This chapter was published as: Anand S., Braga V.M.L. (2016) Cyclodextrins in Ocular Drug Delivery. In: Pathak Y., Sutariya V., Hirani A. (eds) Nano-Biomaterials For Ophthalmic Drug Delivery. Springer, Cham.

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