Methadone and QTc Prolongation in Pain and Palliative Care Patients: A Case Control Study
Methadone (ME) is commonly used in pain and palliative care (PPC) patients with refractory pain or intolerable opioid adverse effects (AEs). A unique ME AE is its QTc interval prolongation risk but most evidence exists in methadone maintenance therapy (MMT) patients. Our goal was to identify QTc interval prolongation risk factors in PPC patients receiving ME and other medications known to prolong the QTc interval and develop a risk stratification tool.
Juba, Katherine; Khadem, Tina; Hutchinson, David; and Brown, Jack (2015). "Methadone and QTc Prolongation in Pain and Palliative Care Patients: A Case Control Study." Pharmacotherapy 35.11, e202-e202.
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