Influence of key polymer attributes, manufacturing conditions and sintering on abuse deterrence of physical barrier type abuse deterrent formulations (ADF)

Authors

Heather Boyce, University of Maryland - Baltimore
Vivek S. Dave, St. John Fisher UniversityFollow
Myke Scoggins, Micromeritics
Dan Smith, Purdue University
Steve Byrn, Purdue University
Bhawana Saluja, U.S. Food and Drug Administration
Wen Qu, U.S. Food and Drug Administration
Vadim J. Gurvich, NIPTE
Stephen W. Hoag, University of Maryland - Baltimore

Document Type

Poster Presentation

Publication Date

11-2016

Abstract

When sintering us used to treat tablet formulations containing polyethylene oxide (PEO), the polymer particles are able to form stronger bonds thereby increase tablet tensile strength. This increase in strength can make it more difficult for an abuser to break, chew, or grind opioid tablets. A mechanistic study was implemented to understand the key sintering factors that influence tensile strength.

Comments

Poster presented at the American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition in Denver, Colorado, November 2016.

Publication Information

Boyce, Heather; Dave, Vivek S.; Scoggins, Myke; Smith, Dan; Byrn, Steve; Saluja, Bhawana; Qu, Wen; Gurvich, Vadim J.; and Hoag, Stephen W., "Influence of key polymer attributes, manufacturing conditions and sintering on abuse deterrence of physical barrier type abuse deterrent formulations (ADF)" (2016). Pharmacy Faculty/Staff Publications. Paper 416.
https://fisherpub.sjf.edu/pharmacy_facpub/416

Please note that the Publication Information provides general citation information and may not be appropriate for your discipline. To receive help in creating a citation based on your discipline, please visit http://libguides.sjfc.edu/citations.