In lieu of an abstract, here is the article's first paragraph:
Bioavailability of multi-vitamins as dietary supplements has always been a concern. Dissolution studies have been successfully used to predict drug release of bioactive molecules, but with vitamins there are some exceptions. United State Pharmacopoeia (USP) defines the dissolution requirements of multi-vitamin supplements based on the composition and type of dosage form. As oil-soluble vitamins do not meet the criterion of “dissolution”, the performance of dosage forms containing such vitamins is evaluated by disintegration studies primarily. Dissolution studies are not applicable for such dosage forms .
Chablani, Lipika (2013). "Rupture Test and Bioavailability of Oil-Soluble Vitamins." Bioequivalence & Bioavailability 5.5, 10000e37-10000e37.
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