Date of Award/Publication
DNP Project Manuscript
Doctor of Nursing Practice
Purpose: The purpose of this review is to compare the effectiveness of induction therapy with arsenic trioxide (ATO) paired with retinoic acid (ATRA) and standard chemotherapy for the treatment of newly diagnosed acute promyelocytic leukemia (APL).
Background and Significance: The use of chemotherapy for APL treatment has demonstrated successful results, but is associated with toxicities. Research has shown that the use of ATO/ATRA not only achieves complete molecular remission, but also increased survival rates and reduced disease relapse.
Methods: Databases used include CINAHL, PubMed, and ProQuest Nursing and Allied Health. Keywords searched were induction treatment, acute promyelocytic leukemia, arsenic trioxide, retinoic acid, and chemotherapy-free.
Results: Overall, patients who received ATO/ATRA compared to those who were treated with ATRA alone or ATRA with chemotherapy demonstrated better event-free survival, less disease relapse, and required less supportive care.
Discussion: Results confirm that the use of ATO/ATRA is the superior choice of induction therapy for patients newly diagnosed with low-risk APL.
Sheldon, Lauren, "Arsenic: It’s Not Just for Rats. The Benefits of Arsenic Trioxide for the Treatment of Acute Promyelocytic Leukemia" (2021). Nursing Doctoral. Paper 12.
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Available for download on Tuesday, November 15, 2022