Date of Award/Publication


Document Type

DNP Project Manuscript

Degree Name

Doctor of Nursing Practice

First Supervisor

Tara Sacco


Purpose: The purpose of this review is to compare the effectiveness of induction therapy with arsenic trioxide (ATO) paired with retinoic acid (ATRA) and standard chemotherapy for the treatment of newly diagnosed acute promyelocytic leukemia (APL).

Background and Significance: The use of chemotherapy for APL treatment has demonstrated successful results, but is associated with toxicities. Research has shown that the use of ATO/ATRA not only achieves complete molecular remission, but also increased survival rates and reduced disease relapse.

Methods: Databases used include CINAHL, PubMed, and ProQuest Nursing and Allied Health. Keywords searched were induction treatment, acute promyelocytic leukemia, arsenic trioxide, retinoic acid, and chemotherapy-free.

Results: Overall, patients who received ATO/ATRA compared to those who were treated with ATRA alone or ATRA with chemotherapy demonstrated better event-free survival, less disease relapse, and required less supportive care.

Discussion: Results confirm that the use of ATO/ATRA is the superior choice of induction therapy for patients newly diagnosed with low-risk APL.


Accepted by Cancer Nursing Practice.

Available for download on Tuesday, November 15, 2022

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