Fisher Digital Publications

Title

Altered Cell-surface Receptor Levels Result from Fructose Advanced Glycation End Product-Induced Inflammation

Authors

Matthew Stryker, St. John Fisher UniversityFollow
Regina Blackley, St. John Fisher UniversityFollow
Melinda E. Lull, St. John Fisher UniversityFollow

Document Type

Poster Presentation

Publication Date

12-2014

Department

Pharmacy

Abstract

Objective: As a result of the heightened reactivity fructose demonstrates compared to glucose and our current knowledge of glucose advanced glycation end-products, the aim of this research was to further elucidate the proinflammatory pathways involved in the response to fru-AGE exposure, including the effects of fru-AGEs on cell-surface receptor expression. We hypothesized that once microglia were activated in response to fru-AGE exposure, there would be an increase in the expression of RAGE and TLR4 to facilitate the proinflammatory cascade.

Comments

Poster presented at at American Society of Health Systems Pharmacy Midyear Clinical Meeting in Anaheim, California, in December 2014.

Publication Information

Stryker, Matthew; Blackley, Regina; and Lull, Melinda E., "Altered Cell-surface Receptor Levels Result from Fructose Advanced Glycation End Product-Induced Inflammation" (2014). Doctoral External Publications. Paper 3.
https://fisherpub.sjf.edu/doctoral_ext_pub/3

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