Title

Abiraterone-induced rhabdomyolysis resulting in acute kidney injury: A case report and review of the literature

Document Type

Article

Publication Date

3-29-2017

Department

Pharmacy

Abstract

Abiraterone, a CYP17 inhibitor, blocks androgen biosynthesis in multiple tissue types. In combination with prednisone, it is approved as a first-line treatment for metastatic castration-resistant prostate cancer. We present a case of rhabdomyolysis associated with abiraterone therapy resulting in acute on chronic kidney injury in a patient with metastatic castration-resistant prostate cancer. Strict monitoring should be employed in patients started on abiraterone who have additional risk factors for developing rhabdomyolysis.

DOI

10.1177/1078155217701294